Since the collapse of the twin towers, Monogenis realised that buildings are meant to live and die, the same way humans do, and, like humans, they too have stories. It is these stories that the artist tries to bring out by isolating architectural ensembles and by placing them in incongruous surroundings, so that they may open up and reveal themselves in a new light.

In general, Dean Monogenis paints on wood or aluminum panels with the use of stencils and tape, and combines abstract elements with painterly components depicted in all the fascinating details. The lines, edges and textures are very important to him. His gesture is premeditated and precise without compromising spontaneity. 

His oeuvre was part of numerous institutional shows: McNay Art Museum (Saint Antonio), Pavillon de l’Arsenal (Paris), Musée d’art moderne de Saint-Etienne Métropole (Saint-Etienne), Schneider Museum of Art (Ashland), Santa Monica Museum of Art, Bronx Museum of Art (New York),  Mykonos Biennale (Mykonos), Angels Gate Cultural Centre (San Pedro), Pace University (New York), Federal Reserve Board (Washington), Hunterdon Art Museum (Clinton, New Jersey), Neuberger Museum (NY), Herter Gallery, (University of Massachusetts, Amherts), Makor-Steinhardt Center (New York), Macedonian Cultural Society (New York), Brooklyn Museum of Art (Brooklyn, New York).

In 2013, Dean Monogenis has received « Artist  in the Market Place (AIM) » award, attributed by Bronx Museum of the Arts (Bronx, NY, USA) and in 2014 he was invited to conceive outdoor sculptures for the museum. In 2013 and 2016 he was granted residency in CCA Andratx, Mallorca, Spain.